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J Thorac Cardiovasc Surg 2006;132:214
© 2006 The American Association for Thoracic Surgery

Letter to the Editor

Use of autologous adult stem cell for treatment of congestive heart failure

Syde A. Taheri, MD

University at Buffalo Medical School, Buffalo, NY

(Email: Staheri268{at}aol.com).

To the Editor:

I read the article by Patel entitled "Surgical treatment for congestive heart failure with autologous adult stem cell transplantation: A prospective randomized study" with great interest. 1-4 Go Clearly the authors have demonstrated the effectiveness of injected autologous bone marrow stem cells to improve the functional capacity of the failing heart. 3-5 Go In this clinical study they had the opportunity to take biopsy specimens of myocardium at the injection sites, but the nature of the cell findings are not reported.

Did the biopsy specimens show the CD34 marker?

Because no information is available in regard to the presence of fibroblasts or scar tissue, would it be possible that these tissues are transforming through dedifferentiation into myocardial tissue instead of stem cell transformation? The implication of this concept will allow investigators to concentrate more on the transduction signal pathway rather than stem cells alone.


   References
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 References
 

  1. Patel AN, Geffner L, Vian RF, et al. Surgical treatment for congestive heart failure with autologous adult stem cell transplantation. a prospective randomized study. J Thorac Cardiovasc Surg 2005;130:1631-1638.[Abstract/Free Full Text]
  2. Edelberg JM, Tang L, Hattori K, et al. Young adult bone marrow-derived endothelial precursor cells restored aging-impaired cardiac angiogenic function. Circ Res 2002;90:E89-E92.
  3. Taheri SA, Hasmat A, Mergige M, et al. Myoangiogenesis after cell patch cardiomyoplasty and omentopexy in a patient with ischemic cardiomyopathy. Tex Heart J 2005;32:1078-1083.
  4. Menasch P, Hagege AA, Viquin JT, et al. Autologous skeletal myoblast transplantation for severe post infarction left ventricular dysfunction. J Am Coll Cardiol 2003;41:1078-1083.[Abstract/Free Full Text]
  5. Taheri SA, Postoloff AV, Stoesser FA. Leg omentopexy for advanced atherosclerosis and lymphedema. Bull Millard Fillmore Hospital Buffalo 1967;14:14-20.




This Article
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Syde A. Taheri
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